Abstract Title:

The protective effect of grape skin or purple carrot extracts against cadmium intoxication in kidney of rats.

Abstract Source:

Pathophysiology. 2019 Aug 12. Epub 2019 Aug 12. PMID: 31924351

Abstract Author(s):

Samuel Rangel Claudio, Flavia Andressa Pidone Ribeiro, Eliene Cezario De Lima, Aline Boveto Santamarina, Luciana Pellegrini Pisani, Camilo Seabra Dias Pereira, Celina Tizuko Fujiyama Oshima, Daniel Araki Ribeiro

Article Affiliation:

Samuel Rangel Claudio


The aim of this study was to evaluate the protective effect of grape skin or purple carrot extracts against cadmium-induced intoxication in rats' kidneys. For this purpose, 30 male Wistar rats were distributed into six groups (n = 5), as follows: control group; cadmium group and groups treated with grape skin at 175 or 350 mg / L doses; or purple carrot extract at 400 mg / L or 800 mg / L doses, by drinking water. In the group exposed to cadmium, histopathological analysis revealed severe tissue injury as a result of coagulation necrosis, congested vessels and inflammatory infiltrate. Animals treated with grape skin or purple carrot extracts improved the histopathological changes induced by cadmium. 8-OHdG immunoexpression and catalase gene expression decreased in rats treated with purple carrot or grape skin extracts. Grape skin extract was able to increase SOD-CuZn gene expression as well. Toll-like signaling pathway (TLR2, PIKK and TRAF6) and cytochrome c expressions were not altered after the treatment with grape skin or purple carrot extracts. Taken together, we conclude that grape skin and purple carrot extracts had a protective effect on the rats' kidneys after cadmium intoxication, by means of tissue regenerating tissue regeneration and antioxidant properties, grape skin extract being more effective for this purpose.

Study Type : Animal Study

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