Abstract Title:

Protective effect of N-acetyl cysteine against radiotherapy-induced cardiac damage.

Abstract Source:

Int J Radiat Biol. 2020 Jan 28:1-32. Epub 2020 Jan 28. PMID: 31990607

Abstract Author(s):

Songul Barlaz Us, Ozden Vezir, Metin Yildirim, Gülsen Bayrak, Serap Yalin, Ebru Balli, Erdinç Yalin, Ulku Comelekoglu

Article Affiliation:

Songul Barlaz Us


Although radiotherapy (RT) is an important component of cancer treatment, it induces adverse tissue reactions in the around of cancer tissue. Therefore, radioprotectives are needed to protect normal tissues. The aim of the present study was to investigate the radioprotective effect of N-acetylcysteine (NAC) on RT- induced cardiac damage in rats for the acute term.The animals were divided into four groups. The rats in control group were injected with saline for 7 days; the rats in NAC group were injected NAC at dose of 240 mg/kg day for 7 days; the rats in RT group were injected with saline for 7 days plus was irradiated 1 hour after the last injection and the rats in NAC + RT group were injected with NAC for 7 days and irradiated 1 hour after the last NAC dose. The electrocardiogram was recorded and evaluated PR interval, QRS duration, QT interval, T wave alterations and heart rate. Serum interleukin-4, interleukin-6, tumor necrosis factor-alpha, interleukin 1 beta, galectin-3 levels and creatine kinase and creatine kinase isoenzyme-MB activities were determined in all groups. Also, tissue malondialdehyde and nitric oxide levels, superoxide dismutase, catalase and glutathione peroxidase activities were determined. In addition, histological changes of heart were evaluated. All measurements were performed 24 hours after RT.In the RT group, findings supporting cardiac injury were observed in the electrocardiogram. Also, cytokine levels and oxidative stress were significantly increased. Pretreatment of rats with NAC ameliorated cardiac injury induced by RT.Our findings suggested that NAC may be a potential radioprotector which is capable of preventing cardiac damage.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.