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Article Publish Status: FREE
Abstract Title:

Protective Effect ofL. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C.

Abstract Source:

ScientificWorldJournal. 2021 ;2021:6618273. Epub 2021 Jul 6. PMID: 34326710

Abstract Author(s):

Eimad Dine Tariq Bouhlali, Mgal Derouich, Abdelbassat Hmidani, Bouchra Bourkhis, Tarik Khouya, Younes Filali-Zegzouti, Chakib Alem

Article Affiliation:

Eimad Dine Tariq Bouhlali

Abstract:

L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotective potential of two date seed varieties, locally known asand, aqueous extracts against paracetamol- (PCM-) driven liver toxicity in 42 Wistar rats. The polyphenol profile was built by means of an HPLC analysis. Hepatic damage was provoked by exposing rats to PCM at a dose of 1.5 g/kg once a week. Besides PCM,anddate seed extracts (200 and 400 mg/kg) were administered orally in a day-to-day routine. Our findings showed that among the examined polyphenol compounds,-coumaric acid, quercetin, caffeic acid, and rutin were the most abundant phytochemicals. Date pits significantly (<0.001) stabilized the PCM-driven alterations in liver function parameters (AST, ALT, ALP, LDH, total protein, direct bilirubin, and total bilirubin). Moreover,pits enhanced considerably (<0.001) the activities of antioxidant enzymes (SOD, CAT, and GPx) as well as the level of reduced glutathione (GSH). The established hepatoprotective effect may be due to the date seeds antioxidant effect and their ability to trap free radicals. The main outcomes of the present study could validate the traditional use of these date seeds to manage various health conditions.

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