Article Publish Status: FREE
Abstract Title:

Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage.

Abstract Source:

Sci Rep. 2018 Nov 1 ;8(1):16199. Epub 2018 Nov 1. PMID: 30385817

Abstract Author(s):

Saki Kawashima, Tomoko Funakoshi, Yasunori Sato, Norikatsu Saito, Hajime Ohsawa, Katsumi Kurita, Kisaburo Nagata, Masayuki Yoshida, Akihito Ishigami

Article Affiliation:

Saki Kawashima


Several studies have reported the effects of vitamin C (L-ascorbic acid, AA) on ultraviolet B (UVB)-induced cell damage using cultured keratinocytes. However, the epidermis consists of multiple cell layers, and the effect of AA on UVB-induced damage to the human epidermis remains unclear. Therefore, we investigated the effect of AA on UVB-induced skin damage using reconstituted human epidermis. The reconstituted human epidermal surface was treated with 100 and 500 mM AA and cultured for 3 h before (pre-AA treatment) or after (post-AA treatment) 120 mJ/cmUVB irradiation. Pre- and post-AA treatments of the epidermal surface suppressed UVB-induced cell death, apoptosis, DNA damage, reactive oxygen species (ROS) production, and the inflammatory response by downregulating tumour necrosis factor-α (TNF-α) expression and release. Moreover, the pre-AA treatment was more effective at preventing UVB-induced skin damage than the post-AA treatment. In summary, pre- and post-AA treatments of the epidermis prevent UVB-induced damage.

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