Abstract Title:

Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats.

Abstract Source:

Andrologia. 2020 Feb 5:e13524. Epub 2020 Feb 5. PMID: 32022330

Abstract Author(s):

Fatih Mehmet Kandemir, Cuneyt Caglayan, Emrah Hicazi Aksu, Serkan Yildirim, Sefa Kucukler, Cihan Gur, Gizem Eser

Article Affiliation:

Fatih Mehmet Kandemir


This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty-five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin-100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl) group received 1.23 mg/kg/b.w. of HgClfor 7 days. Mercury chloride + rutin-50 group received 50 mg/kg/b.w. rutin and HgCl1.23 mg/kg/b.w. for 7 days. HgCl + rutin-100 group received 100 mg/kg/b.w. rutin and HgCl1.23 mg/kg/b.w. for 7 days. It was detected that HgCltreatment increased malondialdehyde (MDA) levels, tumour necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2) expressions, necrosis and degeneration of spermatogonium, dead and abnormal sperm percentages; tubular walls thinning; and decreased antioxidant enzyme activities and sperm motility. It was determined that rutin application reduced testicular damage caused byHgCl. In conclusion, rutin administration may treat HgCltoxicity in testes.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.