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Abstract Title:

Protective effects of 6-gingerol on 6-hydroxydopamine-induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation.

Abstract Source:

J Biochem Mol Toxicol. 2022 Feb ;36(2):e22956. Epub 2021 Nov 16. PMID: 34783140

Abstract Author(s):

Farzaneh-Sadat Rezazadeh-Shojaee, Elham Ramazani, Jamal Kasaian, Zahra Tayarani-Najaran

Article Affiliation:

Farzaneh-Sadat Rezazadeh-Shojaee

Abstract:

Due to many therapeutic effects, Ginger (Zingiber officinale) is the most widely used spice around the world, including in Iran. Due to its potent anti-inflammatory and antioxidant effects, ginger may protect against neurodegenerative disorders. Here, we investigated the effects of 6-gingerol (the main bioactive compound in ginger) on 6-hydroxydopamine (6-OHDA)-induced cell death in PC12 cells. Cell viability, cell apoptosis, and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and survivin expression were measured using resazurin, propidium iodide (PI) and flow cytometry, and western blot analysis. 6-OHDA (100 μM) reduced the cell viability, increased apoptosis, increased the active form of SAPK/JNK, and decreased survivin protein level in PC12 exposed cells in a dose and time-dependent manner. Pretreatment with 6-gingerol significantly increased the viability and reduced apoptosis (2.5 and 5 µM).Also, pretreatment with 6-gingerol at 2.5 and 5 µM increased survivin whereas, 6-gingerol at 2.5 µM reduced (P-SAPK/JNK):(SAPK/JNK) levels to a level near that of the related control. According to the results, 6-gingerol blocks 6-OHDA-induced cell damage by suppressing oxidative stress and anti-apoptotic activity. Thus, 6-gingerol may process beneficial protective effects in slowing the progression of Parkinson's disease.

Study Type : In Vitro Study

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