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Abstract Title:

Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway.

Abstract Source:

Front Pharmacol. 2022 ;13:868393. Epub 2022 Apr 28. PMID: 35571130

Abstract Author(s):

Xue Han, Yakun Yang, Muqing Zhang, Xi Chu, Bin Zheng, Chenxu Liu, Yucong Xue, Shengjiang Guan, Shijiang Sun, Qingzhong Jia

Article Affiliation:

Xue Han

Abstract:

Arsenic trioxide (AsO) induced cardiotoxicity to limit the clinical applications of the effective anticancer agent. 6-Gingerol (6G) is the main active ingredient of ginger, a food with many health benefits. The present study aims to investigate the potential pharmacological mechanisms of 6G on AsO-induced myocardial injury.Fifty KunMing mice were divided into five groups (= 10) receiving: 1) physiological saline; 2) 6G (20 mg/kg) alone; 3) AsO(5 mg/kg); 4) 6G (10 mg/kg) and AsO(5 mg/kg); 5) 6G (20 mg/kg) and AsO(5 mg/kg). 6G was given orally and AsOwas given intraperitoneally once per day for seven consecutive days. Biochemical, histopathological, transmission electron microscopy, ELISA, and western blotting analyses were then performed. Based on the resultant data, AsOwas found to induce cardiotoxicity in mice. 6G significantly ameliorated AsO-induced heart injury, histopathological changes, oxidative stress, myocardial mitochondrial damage, inflammation, and cardiomyocyte apoptosis, while reversed AsO-induced inhibition of the AMPK/SIRT1/PGC-1α pathway.Our experimental results reveal that 6G effectively counteracts AsO-induced cardiotoxicity including oxidative stress, inflammation and apoptosis, which might be attributed to its activation action on AMPK/SIRT1/PGC-1α signaling pathway.

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