Abstract Title:

Protective Effects of Bergamot (Citrus bergamia Risso&Poiteau) Juice in Rats Fed with High-Fat Diet.

Abstract Source:

Planta Med. 2019 Dec 11. Epub 2019 Dec 11. PMID: 31860116

Abstract Author(s):

Marinella De Leo, Eugenia Piragine, Andrea Pirone, Alessandra Braca, Luisa Pistelli, Vincenzo Calderone, Vincenzo Miragliotta, Lara Testai

Article Affiliation:

Marinella De Leo


The bergamot (Risso&Poiteau), a small tree cultivated along the Ionian coast of the Calabria region in Southern Italy, is an ancient plant used for the production of essential oil from fruit peel, but recently evaluated also for the high content of phenolics in the fruit pulp. Indeed, the juice is rich in glycosylated flavone and flavanones, showing a wide range of pharmacological activities. Noteworthy preclinical and clinical studies reported that bergamot juice is effective in reducing plasma lipids. The aim of this study was to evaluate the beneficial effects of ajuice using an experimental animal model of metabolic syndrome and cardiovascular risk. A significant reduction of both triglyceride levels and cardiovascular risk was observed in animals fed with a high-fat diet and bergamot juice. Daily oral treatment with bergamot juice significantly limits a high-fat-induced increase in body, visceral adipose tissue, liver, and heart weight. In addition,juice showed protective effects on hepatic steatosis, probably due to the reduction of oxidative stress and inflammation. Chemical constituents of administered bergamot juice, investigated by means of liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) analyses were represented by a wide range of flavonoids, with neohesperidin, neoeriocitrin, and naringin being the most abundant flavonoids according to previous studies. Furthermore, a considerable amount of brutieridin, a flavanone-glycoside having a 3-hydroxy-3-methyl-glutaryl residue, was observed.

Study Type : Animal Study

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