Article Publish Status: FREE
Abstract Title:

Protective effects ofseed ethanol extract on aluminum chloride-induced testosterone, testicular and hematological changes in an experimental male rat model.

Abstract Source:

Vet Res Forum. 2021 ;12(1):7-13. Epub 2021 Mar 15. PMID: 33953868

Abstract Author(s):

Rita Ifeoma Odo, Chukwuka Nwocha Uchendu, Somtoo Ethelbert Okeke

Article Affiliation:

Rita Ifeoma Odo


The study was done to ascertain the protective potentials of ethanol seed extract ofon aluminum chloride-induced reproductive and hematological toxicities. Thirty mature male rats were used for the study. They were assigned into five groups (n = 6). Group 1 was treated daily with aluminum chloride (100 mg kg)for 8 weeks. Group 2 was treated with aluminum chloride (100 mg kg) andseed extract (CLSE) 200 mg kgsimultaneously for 8 weeks. Group 3 was served as a normal control and given distilled water as a placebodaily for 8 weeks. Group 4 was only treated with CLSE (200 mg kg) for eight weeks. Group 5 was only treated with aluminum chloride (100 mg kg)for 8 weeks and then treated with CLSE (200 mg kg)for another 4 weeks. Testosterone level, testicular weight, sperm motility, gonadal sperm, and extragonadal sperm reserves showed significant increases in group 2 compared to groups 1 and 5. Optimum histoarchitectural protection of the seminiferous tubules was observed in group 2, which did not differ from normal ones. For the hematological parameters, optimum protection was also observed in group 2 compared to other groups. From the results, ethanol seed extract ofdemonstrated protective potentials against aluminum's harmful effects on the male reproductive system and hematology in an experimental male rat model.

Study Type : Animal Study

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