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Abstract Title:

[The protective effects of diallyl sulfide (DAS) on genotoxicity induced by benzene].

Abstract Source:

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Aug 20 ;40(8):568-572. PMID: 36052584

Abstract Author(s):

T Yu, X X Li, R Q Chen

Article Affiliation:

T Yu

Abstract:

To investigate the protective effect of diallyl sulfide (DAS) , against benzene-induced genetic damage in rat.In September 2018, Sixty adult male adaptive feeding 5 days, were randomly divided into six groups according to their weight. Control groups, DAS control groups, benzene model groups, benzene+low DAS groups, benzene+middle DAS groups, benzene+High DAS group, 10 in each group. Rats in the DAS and DAS control group were orally given DAS at 40, 80, 160, 160 mg/kg, blank control and benzene model groups were given corn oil in the same volume. 2 h later, the rats in the benzene model and DAS treatment groups were given gavage administration of benzene (1.3 g/kg) mixed with corn oil (50%, V/V) , blank and DAS control groups were given corn oil in the same volume. Once a day, for 4 weeks. Samples were collected for subsequent testing.Compared with the blank control group, In benzene treated rat, peripheral WBC count was reduced 65.06% (=0.003) , lymphocyte ratiowas reduced (=0.000) , micronucleus rate was increased (=0.000) , Mean fluorescent intensity and relative fluorescence intensity ofγH2AX in BMCs were increased 32.69%、32.64% (=0.001、0.008) , Mean fluorescent intensity and relative fluorescence intensity of γH2AX in PBLs were increased 397.70%、396.26% (=0.000、=0.003) respectively. Compared with the benzene model group, the WBC count increased respectively (=0.000、0.003、0.006) and the micronucleus rate decreased (=0.000、0.000、0.000) in the DAS groups, Mean fluorescent intensity and relative fluorescence intensity ofγH2AX in BMCs were significantly reduced in the high DAS groups (=0.000、0.000) , Mean fluorescent intensity and relative fluorescence intensity ofγH2AX in PBLs were significantly reduced in the low, middle, high DAS groups (=0.000、0.000) .DAS can effectively suppress benzene induced genotoxic damage in rats.

Study Type : Animal Study

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