n/a
Abstract Title:

Protective effects of dietary fish-oil supplementation on skin inflammatory and oxidative stress biomarkers induced by fine particulate air pollution: a pilot randomized, double-blind, placebo-controlled trial.

Abstract Source:

Br J Dermatol. 2021 02 ;184(2):261-269. Epub 2020 Jun 28. PMID: 32333793

Abstract Author(s):

Z Lin, Y Niu, Y Jiang, B Chen, L Peng, T Mi, N Huang, W Li, D Xu, R Chen, H Kan

Article Affiliation:

Z Lin

Abstract:

BACKGROUND: Exposure to fine particulate matter (with an aerodynamic diameter≤ 2·5 μm, PM) air pollution has been associated with skin-related diseases or disorders.

OBJECTIVES: To evaluate the potential skin-protective effects of fish-oil supplementation against PMexposure.

MATERIALS AND METHODS: This is an exploratory analysis based on a pilot randomized, double-blind, placebo-controlled trial among 65 healthy young adults between September 2017 and January 2018 in Shanghai, China. We randomly assigned participants to take either fish oil or placebo 2·5 g daily for four consecutive months. Four rounds of skin D-Squametape samples were collected in the last 2 months, and five secondary biomarkers of skin inflammation and oxidative stress were measured. Fixed-site PMconcentrations on campus were measured in real time. We used linear mixed-effect models to analyse the associations between short-term PMexposure and biomarkers in each group.

RESULTS: The 24-h average PMconcentration was 34·68 ± 15·83 μg m. There were generally weaker associations between PMand biomarkers in the fish-oil group than in the placebo group, but the associations and the between-group differences varied by biomarkers and lag periods. Compared with the placebo group, for a 10-μg mincrease in PMconcentration, the increments of interleukin-1α and carbonyl protein in the fish-oil group were 41·55% smaller [95% confidence interval (CI) 4·61-78·48%] at lag 0-48 h and 22·01% smaller (95% CI 11·25-32·77%) at lag 0-24 h, respectively. No significant between-group differences were observed for other biomarkers.

CONCLUSIONS: This study suggested that dietary fish-oil supplementation may improve biomarkers of skin inflammation and oxidative-stress response to short-term PMexposure.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.