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Abstract Title:

The Protein-Rich Fraction fromExerts Neuroprotection in Hemiparkinsonian Rats by Decreasing Brain Inflammatory-Related Enzymes and Glial Fibrillary Acidic Protein Expressions.

Abstract Source:

J Med Food. 2022 Jul ;25(7):695-709. PMID: 35834631

Abstract Author(s):

Maria Janice Pereira Lopes, Gyllyandeson de Araújo Delmondes, Giovana Mendes de Lacerda Leite, Débora Rejane Alves Cavalcante, PedroÉverson Alexandre de Aquino, Francisco Arnaldo Viana de Lima, Kelly Rose Tavares Neves, Andréa Santos Costa, Hermógenes David de Oliveira, Cícero Francisco Bezerra Felipe, Iri Sandro Pampolha Lima, Marta Regina Kerntopf, Glauce Socorro de Barros Viana

Article Affiliation:

Maria Janice Pereira Lopes

Abstract:

is a cyanobacterium with high protein content and presenting neuroprotective effects. Now, we studied a protein-enriched fraction (SPF), on behavior, neurochemical and immunohistochemical (IHC) assays in hemiparkinsonian rats, distributed into the groups: SO (sham-operated), 6-hydroxydopamine (6-OHDA), and 6-OHDA (treated with SPF, 5 and 10 mg/kg, p.o., 15 days). Afterward, animals were subjected to behavioral tests and euthanized, and brain areas used for neurochemical and IHC assays. SPF partly reversed the changes in the apomorphine-induced rotations, open field and forced swim tests, and also the decrease in striatal dopamine and 3,4-dihydroxyphenylacetic acid contents seen in hemiparkinsonian rats. Furthermore, SPF reduced brain oxidative stress and increased striatal expressions of tyrosine hydroxylase and dopamine transporter and significantly reduced hippocampal inducible nitric oxide synthase, cyclooxygenase-2 and glial fibrillary acidic protein expressions. The data suggest that the protein fraction from, through its brain anti-inflammatory and antioxidative actions, exerts neuroprotective effects that could benefit patients affected by neurodegenerative diseases, like Parkinson's disease.

Study Type : Animal Study

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