Article Publish Status: FREE
Abstract Title:

Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle.

Abstract Source:

Asian Pac J Cancer Prev. 2010 ;11(5):1355-8. PMID: 21198292

Abstract Author(s):

Liang Feng, Xiaobin Jia, Maomao Zhu, Yan Chen, Feng Shi

Article Affiliation:

Liang Feng


Chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lung cancer (NSCLC). The present study aimed to explore the mechanisms of chemoprevention of NSCLC by Prunella vulgaris L. (PV) using a PV extract of 60% ethanol (P-60). In an A/J mouse model benzo[a]pyrene induction of lung tumors was significantly reduced difference by P-60 group. In addition, P-60 was found to have the ability to regulate cell cycle and induce apoptosis in SPC-A-1 cells. Therefore, we propose that P-60 has potential as a lung cancer chemopreventive agent.

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