Abstract Title:

In vitro inhibition of human influenza A virus infection by fruit-juice concentrate of Japanese plum (Prunus mume SIEB. et ZUCC).

Abstract Source:

Biol Pharm Bull. 2008 Mar;31(3):511-5. PMID: 18310920

Abstract Author(s):

Sangchai Yingsakmongkon, Daisei Miyamoto, Nongluk Sriwilaijaroen, Kimie Fujita, Kosai Matsumoto, Wipawee Jampangern, Hiroaki Hiramatsu, Chao-Tan Guo, Toshihiko Sawada, Tadanobu Takahashi, Kazuya Hidari, Takashi Suzuki, Morihiro Ito, Yasuhiko Ito, Yasuo Suzuki


Using a plaque reduction assay, treatment of human influenza A viruses with the fruit-juice concentrate of Japanese plum (Prunus mume SIEB. et ZUCC) showed strong in vitro anti-influenza activity against human influenza A viruses before viral adsorption, but not after viral adsorption, with 50% inhibitory concentration (IC50) values against A/PR/8/34 (H1N1) virus, A/Aichi/2/68 (H3N2) virus and A/Memphis/1/71 (H3N2) virus of 6.35+/-0.17, 2.84+/-1.98 and 0.53+/-0.10 microg/ml, respectively. The plum-juice concentrate exhibited hemagglutination activity toward guinea pig erythrocytes. Its hemagglutination activity was inhibited by the monosaccharide N-acetylneuraminic acid and a sialoglycoprotein (fetuin), but not by the other tested monosaccharides (mannose, galactose, glucose and N-acetylglucosamine), suggesting the presence of a lectin-like molecule(s) in the Japanese plum-juice concentrate. Our findings suggest that the fruit-juice concentrate of Japanese plum may prevent and reduce infection with human influenza A virus, possibly via inhibition of viral hemagglutinin attachment to host cell surfaces by its lectin-like activity.

Study Type : In Vitro Study

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Sayer Ji
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