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Article Publish Status: FREE
Abstract Title:

New trends in pharmacological control of neuropsychiatric symptoms of dementia.

Abstract Source:

Curr Opin Pharmacol. 2021 Dec ;61:69-76. Epub 2021 Oct 9. PMID: 34634603

Abstract Author(s):

Damiana Scuteri, Maria Tiziana Corasaniti, Paolo Tonin, Pierluigi Nicotera, Giacinto Bagetta

Article Affiliation:

Damiana Scuteri

Abstract:

Abnormal neuronal and synaptic plasticity occurs in Alzheimer's disease (AD) and depression. The latter, particularly late-life, has been recognized as fundamental in the identification of at-risk prodromal stages of AD. The lack of disease-modifying drugs and the off-label use of antipsychotics and antidepressants for neuropsychiatric symptoms (NPSs) have caused a season of therapeutic inappropriateness. To date, the wealth of clinical trials investigating drugs, diverse for structure and mechanism of action, has failed to provide a cure for all the spectrums of NPSs. Psychedelics in microdosing afford promotion of neurogenesis and synaptic plasticity and, recently, have been considered a revolution for the management of depression endowed with faster action and an improved side effect profile than antidepressants. In the current scenario, therefore, the rapid-acting antidepressant esketamine could represent the first-in-class for treatment of NPSs, andthis deserves to be demonstrated with an open-label clinical trial.

Study Type : Review

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