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Abstract Title:

RNFPterostilbene effectively inhibits influenza A virus infection by promoting the type I interferon production.

Abstract Source:

Microbes Infect. 2022 Oct 21:105062. Epub 2022 Oct 21. PMID: 36280208

Abstract Author(s):

Wenjiao Wu, Yilu Ye, Yingyuan Zhong, Xiukui Yan, Jianguo Lin, Jianxiang Qiu, Shuwen Liu, Zhixin Fang

Article Affiliation:

Wenjiao Wu

Abstract:

With the prevalence of novel strains and drug-resistant influenza viruses, there is an urgent need to develop effective and low-toxicity anti-influenza therapeutics. Regulation of the type I interferon antiviral response is considered an attractive therapeutic strategy for viral infection. Pterostilbene, a 3,5-dimethoxy analog of resveratrol, is known for its remarkable pharmacological activity. Here, we found that pterostilbene effectively inhibited influenza A virus infection and mainly affected the late stages of viral replication. A mechanistic study showed that the antiviral activity of pterostilbene might promote the induction of antiviral type I interferon and expression of its downstream interferon-stimulated genes during viral infection. The same effect of pterostilbene was also observed in the condition of polyinosinic-polycytidylic acid (poly I:C) transfection. Further study showed that pterostilbene revealed that pterostilbene interacted with influenza non-structural 1 (NS1) protein, inhibit RIG-I ubiquitination mediated degradation of RIG-I and activates the downstream antiviral pathway, orchestrating an antiviral state against influenza virus in the cell. Taken together, pterostilbene could be a promising anti-influenza agent for future antiviral drug exploitation and compounds with similar structures may provide new options for the development of novel inhibitors against influenza A virus (IAV).

Study Type : In Vitro Study

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