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Article Publish Status: FREE
Abstract Title:

Açaí() pulp-enriched diet induces anxiolytic-like effects and improves memory retention.

Abstract Source:

Food Nutr Res. 2022 ;66. Epub 2022 Nov 2. PMID: 36405951

Abstract Author(s):

Tayana Silva de Carvalho, Alódia Brasil, Luana K R Leão, Danielle Valente Braga, Mateus Santos-Silva, Nadyme Assad, Waldo Lucas Luz, Evander de Jesus O Batista, Gilmara de Nazareth Tavares Bastos, Karen Renata Matos Herculano Oliveira, Domingos Luiz Wanderley Picanço Diniz, Anderson Manoel Herculano

Article Affiliation:

Tayana Silva de Carvalho

Abstract:

BACKGROUND: Açaí(Euterpe oleracea) has a rich nutritional composition, showing nutraceutical and protective effects in several organs. In this study, the effects of an açaí-enriched diet on motor performance, anxiety-like behavior, and memory retention were deeply investigated.

METHODS: Eight-week male Wistar rats were fed with an Euterpe oleracea (EO) pulp-enriched diet, an olive oil-enriched (OO) diet (polyunsaturated fatty acid [PUFA] fat control diet), or a chow diet for 31 days (28 days pre-treatment and 3 days during behavioral tests). Afterward, animals were submitted to a battery of behavioral tests to evaluate spontaneous motor behavior (open-field test), anxiety-like behavior (elevated plus maze and open-field test), and memory retention (step-down). Oxidative stress in the hippocampus was evaluated by a lipid peroxidation assay.

RESULTS: EO-enriched diet did not influence the body weight and food intake but increased the glucose plasmatic level after 31 days under this diet. However, a similar fat-enriched diet stimulated a marked weight gain and reduced the food intake, followed by changes in the plasmatic lipid markers. EO-enriched diet preserved the motor spontaneous performance, increased the exploration in the aversive environment (anxiolytic-like effects), and elevated the latency to step-down (improved memory retention). The EO-enriched diet also reduced the level of lipid peroxidation in the hippocampus. These positive effects of EO-enriched diet can greatly support the usage of this diet as a preventive therapy.

CONCLUSION: Taken together, the current study suggests that Euterpe oleracea-enriched diet promotes anxiolytic-like effects and improves memory consolidation, possibly due to the reduced levels of lipid peroxidation in the hippocampus.

Study Type : Animal Study

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