Article Publish Status: FREE
Abstract Title:

Punica granatum L.-derived omega-5 nanoemulsion improves hepatic steatosis in mice fed a high fat diet by increasing fatty acid utilization in hepatocytes.

Abstract Source:

Sci Rep. 2020 09 17 ;10(1):15229. Epub 2020 Sep 17. PMID: 32943651

Abstract Author(s):

K Zamora-López, L G Noriega, A Estanes-Hernández, I Escalona-Nández, S Tobón-Cornejo, A R Tovar, V Barbero-Becerra, C Pérez-Monter

Article Affiliation:

K Zamora-López


Pomegranate seed oil (PSO) is mainly composed of punicic acid (PA), a polyunsaturated fatty acid also known as omega-5 (ω-5), a potent antioxidant associated with a variety of metabolic and cellular beneficial effects. However, the potential benefits of a nanoemulsified version of ω-5 (PSOn) have not been evaluated in a pathological liver condition. Here, we examined whether PSOn had beneficial effects on C57BL/6Nmice fed a high-fat diet (HFD), specifically on hepatic steatosis. We observed that PSOn supplementation decreased body weight and body fat mass in control mice, whereas glucose intolerance, insulin resistance, energy expenditure, and hepatic steatosis were improved in both control mice and in micefed a HFD. Interestingly, PSOn increased fatty acid oxidation in primary hepatocytes and antioxidant gene expression. Altogether, our data indicate that PSOn effectively reduces some of the HFD-derived metabolic syndrome indicators by means of an increase in fatty acid oxidation within hepatocytes.

Study Type : Animal Study

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