Abstract Title:

Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St.-Hil.

Abstract Source:

Toxicol Appl Pharmacol. 2016 Nov 1 ;310:1-8. Epub 2016 Aug 18. PMID: 27546523

Abstract Author(s):

Cristiene Costa Carneiro, Suzana da Costa Santos, Ruy de Souza Lino, Maria Teresa Freitas Bara, Beatriz Abdallah Chaibub, Paulo Roberto de Melo Reis, Dwight Assis Chaves, Antônio Jorge Ribeiro da Silva, Luana Santos Silva, Daniela de Melo E Silva, Lee Chen-Chen

Article Affiliation:

Cristiene Costa Carneiro


Punicalagin is the major ellagitannin constituent from leaves of Lafoensia pacari, a Brazilian medicinal plant widely used for the treatment of peptic ulcer and wound healing. Genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of punicalagin were assessed using micronucleus (MN) test and comet assay in mice. Due to the extensive use of L. pacari in the wound healing process, we also assessed the angiogenic activity of punicalagin using the chick chorioallantoic membrane (CAM) angiogenic assay. The highest dose of punicalagin (50mg/kg) showed significant cytotoxic effect by MN test and in the co-treatment with cyclophosphamide (CPA), this cytotoxicity was enhanced. Co-treatment, pre-treatment and post-treatment of punicalagin with CPA led to a significant reduction in the number of DNA breaks and in the frequency of CPA-induced MN, indicating antigenotoxic effect. Using the CAM model, punicalagin exhibited angiogenic activity in all doses mainly at the lowest concentration (12.5μg/μL). Therefore, these findings indicate an effective chemopreventive role of punicalagin and a high capacity to induce DNA repair. Also, the angiogenic activity presented by punicalagin in this study could contribute for the processes of tissue repairing and wound healing.

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