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Article Publish Status: FREE
Abstract Title:

Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases.

Abstract Source:

Antioxidants (Basel). 2021 Dec 24 ;11(1). Epub 2021 Dec 24. PMID: 35052533

Abstract Author(s):

Jie Xu, Ke Cao, Xuyun Liu, Lin Zhao, Zhihui Feng, Jiankang Liu

Article Affiliation:

Jie Xu

Abstract:

Inflammation is a complex biological defense system associated with a series of chronic diseases such as cancer, arthritis, diabetes, cardiovascular and neurodegenerative diseases. The extracts of pomegranate fruit and peel have been reported to possess health-beneficial properties in inflammation-associated chronic diseases. Punicalagin is considered to be the major active component of pomegranate extracts. In this review we have focused on recent studies into the therapeutic effects of punicalagin on inflammation-associated chronic diseases and the regulatory roles in NF-κB, MAPK, IL-6/JAK/STAT3 and PI3K/Akt/mTOR signaling pathways. We have concluded that punicalagin may be a promising therapeutic compound in preventing and treating inflammation-associated chronic diseases, although further clinical studies are required.

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