Abstract Title:

Efficacy of purslane in the treatment of oral lichen planus.

Abstract Source:

Phytother Res. 2009 Jul 7. PMID: 19585472

Abstract Author(s):

Farzaneh Agha-Hosseini, Katayun Borhan-Mojabi, Hamid-Reza Monsef-Esfahani, Iraj Mirzaii-Dizgah, Shahroo Etemad-Moghadam, Aida Karagah


This study evaluated the effectiveness of antioxidant-rich purslane in the treatment of oral lichen planus (OLP). A total of 37 biopsy-proven symptomatic OLP patients were selected for this randomized double-blind placebo-controlled trial. All subjects were divided into two groups to receive purslane (n = 20) or placebo (n = 17) for 3 months. Assessments were made at baseline, after 2 weeks and each month for 6 months, based on the visual analog scale (VAS) and clinical improvement including lesion type and size. Approximately 83% of the purslane patients showed partial to complete clinical improvement but 17% had no response. In the placebo group 17% experienced partial improvement, 73% did not respond and 10% showed worsening. According to VAS scores, a partial to complete response was observed in all purslane-treated patients, while 71%, 15% and 14% of the controls demonstrated partial response, no response and worsening of the symptoms, respectively. A significant decrease in VAS scores was seen at the end of the study period (p < 0.001). No serious side-effects occurred in either of the groups. According to our findings purslane is clinically effective in the treatment of OLP. Considering the lack of side-effects during the study period, it may be a favorable alternative treatment for OLP. Copyright (c) 2009 John Wiley & Sons, Ltd.

Study Type : Human Study

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