Abstract Title:

Clinical assessment of a supplement of Pycnogenol® and L-arginine in Japanese patients with mild to moderate erectile dysfunction.

Abstract Source:

Phytother Res. 2012 Feb ;26(2):204-7. Epub 2011 May 27. PMID: 21618639

Abstract Author(s):

Hiromitsu Aoki, Junji Nagao, Taro Ueda, Jeffry M Strong, Frank Schonlau, Song Yu-Jing, Yan Lu, Shigeo Horie

Article Affiliation:

Central Laboratories, Kobayashi Pharmaceutical Co., Ltd., 4-4-10 Doshomachi, Chuo-ku, Osaka, Japan.

Abstract:

A double-blind parallel group comparison design clinical study was conducted in Japanese patients with mild to moderate erectile dysfunction to investigate the efficacy of a supplement containing Pycnogenol® and L-arginine. Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, L-arginine 690 mg/day and aspartic acid 552 mg/day) or an identical placebo for 8 weeks, and the results were assessed using the five-item erectile domain (IIEF-5) of the International Index of ErectileFunction. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF-5. In particular, a marked improvement was observed in 'hardness of erection' and 'satisfaction with sexual intercourse'. A decreasein blood pressure, aspartate transaminase and γ-glutamyl transpeptidase (γ-GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with L-arginine as a dietarysupplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.