Abstract Title:

Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases.

Abstract Source:

Phytother Res. 2004 Dec;18(12):1027-8. PMID: 15742344

Abstract Author(s):

Miyako Mochizuki, Noboru Hasegawa

Article Affiliation:

Department of Health and Nutrition, School of Health and Human Life, Nagoya Bunri University, Inazawa, Japan.


Pycnogenol was administered for 10 days by gavage to Sprague-Dawley rats fed an elemental diet, then inflammatory bowel disease (IBD) was induced by intrarectal administration of ethanol 2,4,6-trinitrobenzene sulfonic acid (TNBS). Twelve hours after TNBS treatment, the rats were killed, the colon was assessed by a macroscopic damage score and mucosa homogenate was assayed for myeloperoxidase (MPO) activity. The supplementation of pycnogenol significantly inhibited the macroscopic damage score and MPO activity in a dose-dependent manner. These results suggested that pycnogenol ameliorates TNBS-induced inflammation by radical scavenging activity, and may have beneficial effects as a supplement in enteral nutrition for IBD.

Study Type : Animal Study

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