Abstract Title:

Inhibitory effects of Pycnogenol® (French maritime pine bark extract) on airway inflammation in ovalbumin-induced allergic asthma.

Abstract Source:

Food Chem Toxicol. 2013 Dec ;62:681-6. Epub 2013 Oct 9. PMID: 24120901

Abstract Author(s):

In-Sik Shin, Na-Rae Shin, Chan-Mi Jeon, Ju-Mi Hong, Ok-Kyoung Kwon, Jong-Choon Kim, Sei-Ryang Oh, Kyu-Woung Hahn, Kyung-Seop Ahn

Article Affiliation:

In-Sik Shin


Pycnogenol® (PYC) is a standardized extracts from the bark of the French maritime pine (Pinus maritime) and used as a herbal remedy for various diseases. In this study, we evaluated the effects of PYC on airway inflammation using a model of ovalbumin (OVA)-induced allergic asthma and RAW264.7 cells. PYC decreased nitric oxide production and reduced the interleukine (IL)-1β and IL-6 levels in LPS-stimulated RAW264.7 cells. PYC also reduced the expression of inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9 and enhanced the expression of hemeoxygenase (HO)-1. In the in vivo experiment, PYC decreased the inflammatory cell count and the levels of IL-4, IL-5, IL-13, and immunoglobulin (Ig) E in BALF or serum. These results are consistent with the histological analysis findings, which showed that PYC attenuated the airway inflammation and mucus hypersecretion induced by OVA challenge. In addition, PYC enhanced the expression of HO-1. In contrast, PYC inhibited the elevated expression of iNOS and MMP-9 proteins induced by OVA challenge. In conclusion, PYC exhibits protective effects against OVA-induced asthma and LPS-stimulated RAW264.7 cells. These results suggest thatPYC has potential as a therapeutic agent for the treatment of allergic asthma.

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