Abstract Title:

Pycnogenol®: supplementary management of symptomatic osteoarthritis with a patch. An observational registry study.

Abstract Source:

Minerva Endocrinol. 2019 Mar ;44(1):97-101. PMID: 30561176

Abstract Author(s):

Beatrice Feragalli, Mark Dugall, Roberta Luzzi, Andrea Ledda, Morio Hosoi, Gianni Belcaro, Maria R Cesarone

Article Affiliation:

Beatrice Feragalli


BACKGROUND: The aim of the present observational registry study was to evaluate the efficacy of a thin polycarbonate patch of Pycnogenol® in alleviating symptoms of knee arthrosis, in comparison to the standard management usually applied to treat osteoarthritis (OA).

METHODS: A total of 67 subjects were included in the registry: 34 formed the control group, and 33 entered the active management group in which the Pycnogenol® patch was used. Two Pycnogenol® patches were used every day for three weeks. Each patch contains 110 mg Pycnogenol®. All patients included in this registry suffered from osteoarthritis of the knee.

RESULTS: Results from this study show that Pycnogenol® patch allows faster improvement in OA symptoms, with a decrease in the use of non-steroidal anti-inflammatory drugs and other painkillers. Pycnogenol® patch significally reduced C reactive protein and ESR.

CONCLUSIONS: Pycnogenol® patch was effective in controlling mild to moderate pain and inflammations and its related symptoms in subjects with knee OA over a period of three weeks.

Study Type : Human Study

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