Abstract Title:

Ameliorative effects of pine bark extract on spermatotoxicity byα-chlorohydrin in rats.

Abstract Source:

Phytother Res. 2014 Mar ;28(3):451-7. Epub 2013 Jun 21. PMID: 23788506

Abstract Author(s):

Sung-Hwan Kim, In-Chul Lee, Hyung-Seon Baek, Changjong Moon, Chun-Sik Bae, Sung-Ho Kim, Seung-Chun Park, Hyoung-Chin Kim, Jong-Choon Kim

Article Affiliation:

Sung-Hwan Kim


We investigated the protective effects of pine bark extract (Pycnogenol®, PYC, Horphag Research Ltd., Route de Belis, France) against α-chlorohydrin (ACH)-induced spermatotoxicity in rats. Rats were orally administered ACH (30 mg/kg/day) with or without PYC (20 mg/kg/day) for 7 days. Administration of ACH significantly decreased sperm motility. α-Chlorohydrinalso caused histopathological alterations and apoptotic changes in caput epididymides. An increased malondialdehyde concentration and decreased glutathione content, as well as catalase and glutathione peroxidase activities were also found. In contrast, PYC treatment significantly prevented ACH-induced spermatotoxicity, including decreased sperm motility, histopathological lesions, and apoptotic changes in the caput epididymis. Pycnogenol® also had an antioxidant benefit by decreasing malondialdehyde and increasing levels of the antioxidant glutathione and the activities of the antioxidant enzymes catalase and peroxidase in epididymal tissues. These results indicate that PYC treatment attenuated ACH-induced spermatotoxicity through antioxidant and antiapoptotic effects.

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