Abstract Title:

Pyridoxine (vitamin B6) toxicity: enhancement by uremia in rats.

Abstract Source:

Food Chem Toxicol. 2002 Oct;40(10):1449-51. PMID: 12387307

Abstract Author(s):

S Levine, A Saltzman


Pyridoxine is not completely innocuous. Large doses can cause a peripheral neuropathy despite renal excretion of this water-soluble vitamin. Renal failure patients are treated with pyridoxine to prevent a deficiency. The safety of pyridoxine treatment in the presence of renal dysfunction has not been studied. Our experiments on anephric rats show that the uremic state, in a mere 3 or 4 days, causes a 5- to 10-fold increase in susceptibility to pyridoxine-induced neuronopathy. These results suggest a need for caution in prescribing pyridoxine to uremic patients who will probably take the vitamin daily for many years.


Study Type : Animal Study
Additional Links
Additional Keywords : Cautions : CK(3) : AC(2)

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