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Abstract Title:

Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities.

Abstract Source:

J Nutr Biochem. 2020 Jun 20 ;84:108454. Epub 2020 Jun 20. PMID: 32679549

Abstract Author(s):

Kai Yuan, Qingqing Zhu, Qingyi Lu, Haixu Jiang, Mengmeng Zhu, Xiaohong Li, Guangrui Huang, Anlong Xu

Article Affiliation:

Kai Yuan

Abstract:

Rheumatoid arthritis (RA) is a prototypical autoimmune disorder mainly characterized by joint inflammation and cartilage destruction. Neutrophils actively take part in the initiation and progression of RA. Neutrophils express inflammatory mediators, including cytokines and chemokines. Aberrant formation of neutrophil extracellular traps (NETs) has been demonstrated in the pathogenesis of RA. Thus, neutrophils are regarded as important therapeutic targets in RA treatment. Quercetin is one of the major flavonoids found in fruits and vegetables. Previous studies have demonstrated that quercetin is a potential agent for the treatment of RA. However, the underlying antiarthritic mechanism of quercetin has not been investigated clearly. In this study, we analyzed the therapeutic mechanism of quercetin for RA. Our results showed that quercetin ameliorates inflammation in RA mice by inhibiting neutrophil activities. Quercetin inhibited neutrophil infiltration and reduced the plasma levels of inflammatory cytokines. Quercetin promoted the apoptosis of activated neutrophils. In addition, quercetin inhibited NET formation by suppressing autophagy. These findings suggest that quercetin may be an alternative agent for the treatment of RA by inhibiting neutrophil activities.

Study Type : In Vitro Study

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