Article Publish Status: FREE
Abstract Title:

Novel Effects ofExtract on Patients with Neurocognitive Disorder and Depression: A Clinical Trial Study.

Abstract Source:

Int J Prev Med. 2018 ;9:57. Epub 2018 Jun 29. PMID: 30050668

Abstract Author(s):

Ebrahim Esfandiary, Zahra Abdolali, Victoria Omranifard, Mustafa Ghanadian, Reza Bagherian-Sararoud, Mohammad Karimipour, Behzad Mahaki, Shahriar Dabiri

Article Affiliation:

Ebrahim Esfandiary


Background: Dementia as a major cognitive neurological disorder is defined as impairment in one or more cognitive territories compared with the former level of performance. This disorder disrupts patient's independence, and the patient would need others aid in order of doing daily and complex activities. The aim of this study was to evaluate the efficacy of Rosa damascena extract in the improvement of cognitive function in patients with dementia.

Methods: This study is a randomized double-blind, placebo-controlled clinical trial on 40 patients older than 55 years with dementia referred to Specialized Elderly Patients Clinic in 2015-2016. Patients were divided randomly into two groups (control and intervention). The intervention group used donepezil andcapsules, and in control group, placebo capsule instead ofadded on donepezil. Four test was filled three times at the study initiation, after month one and also after month three: Mini-Mental State Examination (MMSE) and Addenbrooke's Cognitive Examination Revised (ACE-R) were used for cognition evaluation, for depression assessment, Geriatric Depression Scale was administered, and checklist of memory and behavioral disorders were filled.

Results: The results showed add-on donepezil andversus placebo improved cognitive impairment based on MMSE with= 0.002, ACE-R with total= 0.001, depression (= 0.012), behavioral disorders (<0.001), and daily activity (<0.001).

Conclusions: Theextract affected cognitive impairment of dementia patients significantly and also have significant effects on improving depression and behavioral problems.

Study Type : Human Study

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