Abstract Title:

"Early death" and the contraindication of vaccine during treatment of rabies.

Abstract Source:

Vaccine. 2009 Nov 27;27(51):7173-7. PMID: 19925949

Abstract Author(s):

Rodney E Willoughby

Article Affiliation:

Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI 53201-1997, USA. [email protected]


Administration of rabies vaccine or rabies immune globulin (RIG) during symptomatic rabies is ineffective, and there are concerns about the phenomenon of "early death" reported in animals that develop rabies after receipt of rabies vaccine or immune globulin. Survival analyses of the original animal data confirm these findings in two species, whereas analyses of human case reports and the Milwaukee Protocol registry suggest lower risk of "early death" in humans. There may be a deleterious interaction of rabies vaccine and RIG with bat rabies in humans. Animal studies of bat rabies virus with bat-origin vaccines and RIG are urgently needed.

Study Type : Animal Study
Additional Links
Anti Therapeutic Actions : Vaccination: Rabies : CK(43) : AC(15)

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