Abstract Title:

[Effect of ranitidine on secretion of gastric intrinsic factor and absorption of vitamin B 12].

Abstract Source:

Gastroenterol Clin Biol. 1983 Apr ;7(4):381-4. PMID: 6135642

Abstract Author(s):

J Bélaïche, J Zittoun, J Marquet, Y Nurit, J Yvart


The effects of ranitidine, a new potent histamine H2-receptor antagonist, on gastric intrinsic factor (IF) secretion and protein-bound cobalamin absorption were evaluated in 6 patients with duodenal ulcer, before, during and after discontinuation of ranitidine therapy. Oral ranitidine (150 mg twice a day) resulted in a non significant decrease of IF concentration and IF output but was responsible for malabsorption of protein-bound cobalamin. This malabsorption was reversible upon discontinuation of ranitidine. These results indicate that occurrence of cobalamin deficiency cannot be excluded during long-term ranitidine treatment and emphasize the need for careful follow-up in these patients.

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