Abstract Title:

Longitudinally extensive transverse myelitis following vaccination with nasal attenuated novel influenza A(H1N1) vaccine.

Abstract Source:

Arch Neurol. 2010 Aug;67(8):1018-20. PMID: 20697056

Abstract Author(s):

Wafa Akkad, Bassel Salem, Jerome W Freeman, Mark K Huntington

Article Affiliation:

Center for Family Medicine, 1115 E 20th St, Sioux Falls, SD 57105, USA.


BACKGROUND: Transverse myelitis has been reported in association with vaccination, including influenza vaccination. OBJECTIVE: To describe a case of longitudinally extensive transverse myelitis associated with vaccination with a nasal attenuated novel influenza A(H1N1) vaccine. DESIGN: Case report. SETTING: Sanford University of South Dakota Hospital. Patient A 27-year-old woman with longitudinally extensive transverse myelitis. RESULTS: Four days following novel influenza A(H1N1) vaccination, the patient developed longitudinally extensive transverse myelitis. Extensive diagnostic evaluation effectively ruled out causes other than vaccination-associated transverse myelitis. Following treatment with corticosteroids and plasmapheresis, the patient made a significant recovery. CONCLUSIONS: Transverse myelitis may be associated with vaccination against novel influenza A(H1N1). Additionally, we believe this to be the first report of longitudinally extensive transverse myelitis associated with any vaccine.

Study Type : Human: Case Report

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