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Article Publish Status: FREE
Abstract Title:

BEHAVIORAL EVIDENCE OF ANTIDEPRESSANT-LIKE ACTIVITY OFL. VAR.IN MICE.

Abstract Source:

Afr J Tradit Complement Altern Med. 2017 ;14(3):142-146. Epub 2017 Mar 1. PMID: 28480425

Abstract Author(s):

Ishrat Younus, And Afshan Siddiq

Article Affiliation:

Ishrat Younus

Abstract:

BACKGROUND: Currently-available antidepressant agents produce various adverse effects, and are expensive. At present, various plants are being evaluated for their possible role against numerous diseases, and no doubt, the role of traditional and complementary medicines in the development of effective therapy is incredible. The present study was designed to evaluate antidepressant-like activity ofL. Var.at different doses in mice.

MATERIALS AND METHODS: Antidepressant potential of ethanolic extract ofL. was evaluated at three different doses 250 mg/kg, 500 mg/kg and 1000 mg/kg by using forced swim test and tail suspension test on albino male mice. The results were compared with control and standard mice groups administered with normal saline and Fluoxetine respectively. In both parameters immobility period was recorded two times during 60 days dosing.

RESULTS: The ethanol extract at all three tested doses (250 mg/kg, 500 mg/kg and 1000 mg/kg) and standard fluoxetine demonstrated notable antidepressant-like activity (p<0.05) in both FST and TST paradigms.

CONCLUSION: Our results clearly show thatameliorate depression-like behavior in rodent model, and can be used to establish newer antidepressant approaches in future. However, mechanism-based studies are needed to establish the mechanistic action ofL.EERC Ethanol Extract ofFST Forced swim test: TSTTail suspension test.

Study Type : Animal Study

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