Article Publish Status: FREE
Abstract Title:

Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting.

Abstract Source:

Front Pharmacol. 2016 ;7:221. Epub 2016 Jul 26. PMID: 27507945

Abstract Author(s):

Erin M Rock, Linda A Parker

Article Affiliation:

Erin M Rock


Despite the advent of classic anti-emetics, chemotherapy-induced nausea is still problematic, with vomiting being somewhat better managed in the clinic. If post-treatment nausea and vomiting are not properly controlled, anticipatory nausea-a conditioned response to the contextual cues associated with illness-inducing chemotherapy-can develop. Once it develops, anticipatory nausea is refractive to current anti-emetics, highlighting the need for alternative treatment options. One of the first documented medicinal uses ofΔ(9)-tetrahydrocannabinol (Δ(9)-THC) was for the treatment of chemotherapy-induced nausea and vomiting (CINV), and recent evidence is accumulating to suggest a role for the endocannabinoid system in modulating CINV. Here, we review studies assessing the therapeutic potential of cannabinoids and manipulations of the endocannabinoid system in human patients and pre-clinical animal models of nausea and vomiting.

Study Type : Review

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