Abstract Title:

Silver nanoparticles-induced nephrotoxicity in rats: the protective role of red beetroot (Beta vulgaris) juice.

Abstract Source:

Environ Sci Pollut Res Int. 2020 Jul 7. Epub 2020 Jul 7. PMID: 32638302

Abstract Author(s):

Tarfa Albrahim

Article Affiliation:

Tarfa Albrahim


The present study was designed to investigate the nephrotoxicity of silver nanoparticles (AgNPs; 80 mg/kg;> 100 nm) and to evaluate the protective effect exercised by Beta vulgaris (beetroot) juice (RBR; 200 mg/kg) on male rats' kidney. Serum-specific parameters (urea, creatinine, electrolytes and histopathology of kidney tissue) were examined to assess the AgNPs nephrotoxicity effect. Moreover, thisstudy analysed oxidative stress (lipid peroxidation, glutathione, superoxide dismutase and catalase) and anti-apoptotic markers (Bcl-2). AgNPs intoxication increased kidney function marker levels and lipid peroxidation and decreased the glutathione, superoxide dismutase and catalase activities in kidney tissue. Additionally, Bcl-2 expression was downregulated following AgNPs intoxication. Moreover, AgNPs induced a significant increase in renal DNA damage displayed as an elevation in tail length, tail DNA percentage and tail moment. Interestingly, RBR post-treatment restored the biochemical and histological alterations induced by AgNPs exposure, reflecting its nephroprotective effect. Collectively, the present data suggest that RBR could be used as a potential therapeutic intervention to prevent AgNPs-induced nephrotoxicity.

Study Type : Animal Study

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Sayer Ji
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