Article Publish Status: FREE
Abstract Title:

Red Clover (Trifolium pratense L.) Sprout Prevents Metabolic Syndrome.

Abstract Source:

J Nutr Sci Vitaminol (Tokyo). 2020 ;66(1):48-53. PMID: 32115453

Abstract Author(s):

Shin-Ichiro Yokoyama, Miyuki Kodera, Akiko Hirai, Mitsuhiko Nakada, Yuki Ueno, Toshihiko Osawa

Article Affiliation:

Shin-Ichiro Yokoyama


We examined the prevention effect of red clover (Trifolium pratense L.) sprout on metabolic syndrome using a high-carbohydrate and high-fat diet (Western diet; WD)-induced male C57BL/6J obese model mouse. Red clover sprout-lyophilized powder (RC) contained 3.5 mg/g dry-weight of formononetin as a major phenolic compound, as analyzed by high performance liquid chromatography. Supplementation of 0.3% (w/w) RC in a WD (WD+RC) showed an anti-obesity effect and ameliorated lipid metabolism in the obese model mice. Additionally, fasting plasma glucose levels were significantly reduced in the WD+RC group. Administration of 0.1 mg/kg formononetin reduced the postprandial blood glucose level, as assessed using the oral maltose tolerance test. However, no significant formononetin intake effect was observed on the plasma insulin level. These results suggest that the formononetin contained in red clover sprout inhibitsα-glucosidase and thereby contributes to reducing the postprandial blood glucose response in mice.

Study Type : Animal Study

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