Abstract Title:

Red propolis ameliorates ischemic-reperfusion acute kidney injury.

Abstract Source:

Phytomedicine. 2015 Aug 15 ;22(9):787-95. Epub 2015 Apr 12. PMID: 26220625

Abstract Author(s):

Marcus Felipe Bezerra da Costa, Alexandre Braga Libório, Flávio Teles, Conceição da Silva Martins, Pedro Marcos Gomes Soares, Gdayllon C Meneses, Francisco Adelvane de Paulo Rodrigues, Luzia Kalyne Almeida Moreira Leal, Diogo Miron, Aline Holanda Silva, Alice Maria Costa Martins

Article Affiliation:

Marcus Felipe Bezerra da Costa


INTRODUCTION: Acute kidney injury (AKI) remains a great problem in clinical practice. Renal ischemia/reperfusion (I/R) injury is a complex pathophysiological process. Propolis is a natural polyphenol-rich resinous substance collected by honeybees from a variety of plant sources that has anti-inflammatory and anti-oxidative properties. Red propolis (RP) protection in renal I/R injury was investigated.

METHODS: Male Wistar rats underwent unilateral nephrectomy and contralateral renal I/R (60 min). Rats were divided into four groups: (1) sham group, (2) RP group (sham-operated rats treated with RP), 3) IR group (rats submitted to ischemia) and (4) IR-RP (rats treated with RP before ischemia). At 48 h after reperfusion, renal function was assessed and kidneys were removed for analysis.

RESULTS: I/R increased plasma levels of creatinine and reduced creatinine clearance (CrCl), and RP provided protection against this renal injury. Red propolis significantly improves oxidative stress parameters when compared with the IR group. Semiquantitative assessment of the histological lesions showed marked structural damage in I/R rats compared with the IR-RP rats. RP attenuates I/R-induced endothelial nitric oxide-synthase down regulation and increased heme-oxygenase expression in renal tissue.

CONCLUSION: Red propolis protects kidney against acute ischemic renal failure and this protection is associated with reduced oxidative stress and eNOS and heme-oxygenase up regulation.

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