Abstract Title:

Effect of salvianolic acid A, a depside from roots of Salvia miltiorrhiza, on gastric H+,K(+)-ATPase.

Abstract Source:

Planta Med. 1990 Aug;56(4):360-3. PMID: 2173008

Abstract Author(s):

S Murakami, H Kijima, Y Isobe, M Muramatsu, H Aihara, S Otomo, L N Li, C B Ai

Article Affiliation:

Research Center, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan.


Salvianolic acid A, a depside from the roots of Salvia miltiorrhiza, inhibited pig gastric H+,K(+)-ATPase and pNPPase with 50% inhibition values (IC50) of 5.2 x 10(-7) M and 1.7 x 10(-6) M, respectively. Kinetic studies revealed that the inhibition patterns induced by salvianolic acid A were competitive with respect to ATP and noncompetitive with respect to K+. Salvianolic acid A (25 mg/kg, i.p.) significantly inhibited acid secretion in pylorus-ligated rats. At the same dose it also showed a significant reduction in the formation of gastric lesion induced by water immersion and restraint stress. These results suggest that salvianolic acid A shows antisecretory and antiulcer activity by inhibiting the gastric H+,K(+)-ATPase.

Study Type : Animal Study

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