n/a
Article Publish Status: FREE
Abstract Title:

Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study.

Abstract Source:

Nutrients. 2020 Nov 2 ;12(11). Epub 2020 Nov 2. PMID: 33147894

Abstract Author(s):

Gaëlle Annweiler, Mathieu Corvaisier, Jennifer Gautier, Vincent Dubée, Erick Legrand, Guillaume Sacco, Cédric Annweiler

Article Affiliation:

Gaëlle Annweiler

Abstract:

BACKGROUND: The objective of this quasi-experimental study was to determine whether bolus vitamin D supplementation taken either regularly over the preceding year or after the diagnosis of COVID-19 was effective in improving survival among hospitalized frail elderly COVID-19 patients.

METHODS: Seventy-seven patients consecutively hospitalized for COVID-19 in a geriatric unit were included. Intervention groups were participants regularly supplemented with vitamin D over the preceding year (Group 1), and those supplemented with vitamin D after COVID-19 diagnosis (Group 2). The comparator group involved participants having received no vitamin D supplements (Group 3). Outcomes were 14-day mortality and highest (worst) score on the ordinal scale for clinical improvement (OSCI) measured during COVID-19 acute phase. Potential confounders were age, gender, functional abilities, undernutrition, cancer, hypertension, cardiomyopathy, glycated hemoglobin, number of acute health issues at admission, hospital use of antibiotics, corticosteroids, and pharmacological treatments of respiratory disorders.

RESULTS: The three groups (= 77; mean± SD, 88 ± 5years; 49% women) were similar at baseline (except for woman proportion,= 0.02), as were the treatments used for COVID-19. In Group 1 (= 29), 93.1% of COVID-19 participants survived at day 14, compared to 81.2% survivors in Group 2 (= 16) (= 0.33) and 68.7% survivors in Group 3 (= 32) (= 0.02). While considering Group 3 as reference (hazard ratio (HR) = 1), the fully-adjusted HR for 14-day mortality was HR = 0.07 (= 0.017) for Group 1 and HR = 0.37 (= 0.28) for Group 2. Group 1 had longer survival time than Group 3 (log-rank= 0.015), although there was no difference between Groups 2 and 3 (log-rank= 0.32). Group 1, but not Group 2 (= 0.40), was associated with lower risk of OSCI score≥5 compared to Group 3 (odds ratio = 0.08,= 0.03).

CONCLUSIONS: Regular bolus vitamin D supplementation was associated with less severe COVID-19 and better survival in frail elderly.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.