Abstract Title:

Rehmannia inhibits adipocyte differentiation and adipogenesis.

Abstract Source:

Biochem Biophys Res Commun. 2008 Jun 27;371(2):185-90. Epub 2008 Apr 3. PMID: 18395006

Abstract Author(s):

Lin Jiang, Nai-xian Zhang, Wei Mo, Rui Wan, Chun-gu Ma, Xi Li, Yin-liang Gu, Xin-ying Yang, Qi-qun Tang, Hou-yan Song


Rehmannia glutinosa, a Traditional Chinese Medicine (TCM), has been used to increase physical strength. Here, we report that Rehmannia glutinosa extract (RE) inhibits adipocyte differentiation and adipogenesis. RE impairs differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. At the molecular level, treatment with RE inhibits expression of the key adipocyte differentiation regulator C/EBPbeta, as well as C/EBPalpha and the terminal marker protein 422/aP2, during differentiation of preadipocytes into adipocytes. Additionally, RE inhibits the mitotic clonal expansion (MCE) process of adipocyte differentiation, and RE prevents localization of C/EBPbeta to the centromeres. RE also prevents high fat diet (HFD) induced weight gain and adiposity in rats. Taken together, our results indicate that Rehmannia glutinosa extract inhibits preadipocyte differentiation and adipogenesis in cultured cells and in rodent models of obesity.

Study Type : Animal Study

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