Reishi has anti-androgen effects. - GreenMedInfo Summary

Abstract Title:

Anti-androgen effects of extracts and compounds from Ganoderma lucidum.

Abstract Source:

Chem Biodivers.2009 Feb;6(2):231-43. PMID: 19235153

Abstract Author(s):

Jie Liu, Sadaaki Tamura, Kenji Kurashiki, Kuniyoshi Shimizu, Kiyoshi Noda, Fumiko Konishi, Shoichiro Kumamoto, Ryuichiro Kondo


The 30% EtOH extracts of Ganoderma lucidum Fr. Karst (Ganodermateceae) showed weak 5alpha-reductase inhibitory activity and binding ability to androgen receptor. When LNCaP (lymph-node carcinoma of the prostate) cells were treated with the EtOH extracts, cell proliferation was inhibited. Treatment with the extracts significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer. From the 30% EtOH extracts, we isolated ganoderiol F, which showed binding activity to androgen receptor and inhibited LNCaP cell proliferation, as one of the active compounds in the 30% EtOH extracts 

Study Type : In Vitro Study

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