Article Publish Status: FREE
Abstract Title:

Rejuvenating the Brain With Chronic Exercise Through Adult Neurogenesis.

Abstract Source:

Front Neurosci. 2019 ;13:1000. Epub 2019 Sep 18. PMID: 31619959

Abstract Author(s):

Mariela F Trinchero, Magalí Herrero, Alejandro F Schinder

Article Affiliation:

Mariela F Trinchero


The aging brain presents a general decline in plasticity that also affects hippocampal neurogenesis. Besides the well-known reduction in the rate of neuronal generation, development of new neurons is largely delayed in the aging brain. We have recently shown that this slow development is accelerated when middle-aged mice perform voluntary exercise in a running wheel. It is unclear whether the effects of exercise on neurogenic plasticity are persistent in time in a manner that might influence neuronal cohorts generated over an extended time span. To clarify these issues, we examined the effects of exercise length in 3-week-old neurons and found that their development is accelerated only when running occurs for long (3-4 weeks) but not short periods (1 week). Furthermore, chronic running acted with similar efficiency on neurons that were born at the onset, within, or at the end of the exercise period, lasting until 3 months. Interestingly, no effects were observed on neurons born 1 month after exercise had ended. Our results indicate that multiple neuronal cohorts born throughout the exercise span integrate very rapidly in the aging brain, such that the effects of running will accumulate and expand network assembly promoted by neurogenesis. These networks are likely to be more complex than those assembled in a sedentary mouse due to the faster and more efficient integration of new neurons.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Neurogenesis : CK(215) : AC(109)

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