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Abstract Title:

Antihypertensive Activity of Prunus armeniaca in Hypertensive Rats.

Abstract Source:

Cardiovasc Hematol Agents Med Chem. 2022 Jun 13. Epub 2022 Jun 13. PMID: 35702770

Abstract Author(s):

Ismail Bouadid, Mourad Akdad, Mohamed Eddouks

Article Affiliation:

Ismail Bouadid

Abstract:

AIMS: The goal of this work was to evaluate the antihypertensive activity of Prunus armeniaca.

BACKGROUND: Prunus armeniaca is known for its beneficial medicinal properties.

OBJECTIVE: This study aimed to evaluate the effect of the aqueous extract of Prunus armeniaca L. (P. armeniaca) leaves (PAAE) on arterial blood pressure in normotensive and hypertensive rats.

MATERIALS AND METHODS: In the in vivo examination, N-omega-Nitro-L-arginine methyl ester hydrochloride(L-NAME)-induced hypertensive and normotensive rats have received orally PAAE (160 and 100 mg/kg) during six hours for the acute experiment and during seven days for the subchronic treatment and blood pressure parameters were evaluated. In the in vitro experiment, isolated intact thoracic aortic rings were precontracted with KCl (80 mM) and epinephrine (EP) (10μM) and vascular dilatation was assessed.

RESULTS: PAAE lowered blood pressure parameters in L-NAME-induced hypertensive, without affecting normotensive rats following oral administration, suggesting that PAAE possesses an antihypertensive effect. In addition, PAAE (0.25-1 mg/mL) revealed a vasorelaxant effect in thoracic aortic rings precontracted by EP (10μM), and this effect was especially reduced in the presence of glibenclamide or nifedipine. However, PAAE (0.25-1 mg/mL) had only a minimal vasorelaxant effect on thoracic aortic rings precontracted by KCl (80 mM).

CONCLUSION: The results demonstrate that the P. armeniaca aqueous extract possesses potent antihypertensive and vasorelaxant activity and its vasorelaxant activity seems to be mediated through opening of ATP-sensitive K+ channels and inhibition of L-type calcium channels.

Study Type : Animal Study

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