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Article Publish Status: FREE
Abstract Title:

'Namdokmai' Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in aModel of Alzheimer's Amyloidosis.

Abstract Source:

Pharmaceuticals (Basel). 2022 May 11 ;15(5). Epub 2022 May 11. PMID: 35631418

Abstract Author(s):

Piya Temviriyanukul, Suwapat Kittibunchakul, Piyapat Trisonthi, Thanit Kunkeaw, Woorawee Inthachat, Dalad Siriwan, Uthaiwan Suttisansanee

Article Affiliation:

Piya Temviriyanukul

Abstract:

Alzheimer's disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including'Phulae','Pattavia','Khaekdum','Khaeknuan','Monthong','Chanee','Kimju','Keenok','Kaew' and'Namdokmai' were screened for their inhibitory activities against the key enzymes, cholinesterases andβ-secretase (BACE-1), involved in AD pathogenesis. The top three fruit extracts with promising in vitro anti-AD activities were further investigated using rat pheochromocytoma PC-12 neuronal cell line andAD model. Data showed that'Kaew','Namdokmai' and'Kimju' reduced Aβ-mediated neurotoxicity by promoting glutathione-dependent enzymes, while'Namdokmai' limited Aβpeptide formation via BACE-1 inhibition and amended locomotory behavior of theAD model. Results indicated the potential anti-AD properties of tropical fruits, particularly'Namdokmai' in the prevention of Aβ-mediated neurotoxicity and as a BACE-1 blocker.

Study Type : Insect Study

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