n/a
Article Publish Status: FREE
Abstract Title:

Hepatoprotective Effect of Camel Milk on Poloxamer 407 Induced Hyperlipidaemic Wistar Rats.

Abstract Source:

Open Access Maced J Med Sci. 2017 Dec 15 ;5(7):852-858. Epub 2017 Nov 30. PMID: 29362609

Abstract Author(s):

Jibril Zuberu, Malajiya I A Saleh, Abdul Wahab Alhassan, Bello Y Adamu, Munira Aliyu, Bilkisu T Iliya

Article Affiliation:

Jibril Zuberu

Abstract:

AIM: To investigate the effect of oral administration of camel milk on liver enzymes, total proteins and histology of poloxamer 407 induced hyperlipidaemic wistar rats.

MATERIAL AND METHODS: Thirty male wistar rats weighing between 150-200 g were randomly assigned into six groups of five each; group I: administered distilled water, group II: induced with P407, group III: induced with P407 and treated with atorvastatin (20 mg/kg) and groups IV, V and VI: induced with P407 and treated with camel milk 250 mg/kg, 500 mg/kg and 1000 mg/kg respectively. After three weeks, blood samples and liver tissues were collected for the determination of alkaline phospatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, albumin/globulin ratio and histological studies respectively.

RESULTS: All camel milk treated groups showed significant (p<0.05) decrease in ALT and AST. Camel milk treated groups; 250 mg/kg and 1000mg/kg showed significant (p<0.05) decrease in total protein, globulin with all camel milk treated groups having significant (p<0.05) increase in A/G ratio. Histological examination of liver tissues showed that camel milk at a dose of 250 mg/kg had slight adipocytes infiltration.

CONCLUSION: The results of our findings highlight the hepatoprotective effect of camel milk in poloxamer 407 induced hyperlipidaemic wistar rats.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.