Abstract Title:

The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial.

Abstract Source:

Rev Bras Ginecol Obstet. 2021 Jan 19. Epub 2021 Jan 19. PMID: 33465795

Abstract Author(s):

Mahboobeh Shirazi, Mohamad Naser Jalalian, Masoumeh Abed, Marjan Ghaemi

Article Affiliation:

Mahboobeh Shirazi


OBJECTIVE:  The present study aimed to assess the effect of(a combination of lemon balm with fennel fruit extract) compared with citalopram and placebo on the quality of life of postmenopausal women with sleep disturbance.

METHODS:  The present study is a randomized, double-blind, placebo clinical trial among 60 postmenopausal women with sleep disturbance who were referred to a university hospital from 2017 to 2019. The participants were randomized to receive(500 mg daily), citalopram (30 mg) or placebo once daily for 8 weeks. The Menopause-Specific Quality of Life (MENQOL) questionnaire was self-completed by each participant at baseline and after 8 weeks of the intervention and was compared between groups.

RESULTS:  The mean for all MENQOL domain scores were significantly improved in thegroup compared with citalopram and placebo ( < 0.001). The mean ± standard deviation (SD) after 8 weeks in thecitalopram and placebo groups was 2.2 ± 0.84 versus 0.56 ± 0.58 versus 0.36 ± 0.55 in the vasomotor ( < 0.001), 1.02 ± 0.6 versus 0.28 ± 0.2 versus 0.17 ± 0.1 in the psychomotor-social ( < 0.001), 0.76 ± 0.4 versus 0.25 ± 0.1 versus 0.11 ± 0.1 in the physical and 2.3 ± 1.0 versus 0.35 ± 0.5 versus 0.41 ± 0.5 in the sexual domain, respectively.

CONCLUSIONS:  The results revealed thatmay be recommended for improving the quality of life of menopausal women with sleep disturbance.

TRIAL REGISTRATION:  The present study was registered by the name"Comparison of the efficacy of citalopram and compound ofandin treatment of menopausal disorders"with the code IRCT2013072714174N1 in the Iranian Registry of Clinical Trials (IRCT).

Study Type : Human Study

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Sayer Ji
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