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Article Publish Status: FREE
Abstract Title:

Inhibition ofβ-elemene on the expressions of HIF-lα, VEGF and iNOS in diabetic rats model.

Abstract Source:

Int J Ophthalmol. 2019 ;12(11):1693-1698. Epub 2019 Nov 18. PMID: 31741856

Abstract Author(s):

Yun Zhou, Yan Liu, Jun Chen, Yi-Zhou Sun, Li-Hua Li, Lei Chen

Article Affiliation:

Yun Zhou

Abstract:

AIM: To evaluate the effect ofβ-elemene on the expressions of hypoxia-inducible factor (HIF)-lα, vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in a streptozotocin (STZ) induced diabetic Sprague-Dawley (SD) rat model.

METHODS: SD rats were administered an abdominal injection of STZ and induced to a diabetic model. After 6wk course of diabetes, the treatment groups were givenβ-elemene through periocular and intravitreous injection separately and the control groups were given blank emulsion injection. HE staining was used to observe the morphology of retina. The mRNA expressions of HIF-1α, VEGF and iNOS was assayed by real-time polymerase chain reaction (PCR) and the protein expression was measured by Western blot and immunocytochemistry methods.

RESULTS: The results indicated that the protein and mRNA expressions of HIF-1α, VEGF and iNOS after treated by β-elemene periocularly and intravitreally injections were all found to be reduced compared with the levels in the diabetic rats group (<0.05). The inhibitory effect of intravitreal injection was more remarkable.

CONCLUSION: The results showβ-elemene protect the retina of diabetic rats from high glucose damage by downregulating the expression of HIF-1α, VEGF and iNOS.

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