Article Publish Status: FREE
Abstract Title:

Ascorbic acid induces apoptosis in adult T-cell leukemia.

Abstract Source:

Anticancer Res. 2007 Jan-Feb;27(1A):289-98. PMID: 17352246

Abstract Author(s):

Steve Harakeh, Mona Diab-Assaf, Jihane C Khalife, Khalil A Abu-el-Ardat, Elias Baydoun, Aleksandra Niedzwiecki, Marwan E El-Sabban, Mathias Rath

Article Affiliation:

Steve Harakeh


BACKGROUND: Adult T-cell leukemia (ATL) is an acute malignancy of activated T-cells caused by the human T-cell lymphotrophic virus type-1 (HTLV-1).

MATERIALS AND METHODS: The effects of non-cytotoxic concentrations of ascorbic acid (AA) were evaluated against HTLV-1 positive and negative cells. The effect of AA on apoptosis and proliferation was evaluated by cell cycle analysis. The role of p53, p21 Bax and Bcl-2a on cell cycle modulation and apoptosis was also assessed. The anti-proliferative effects were tested by determining the changes in the expression of transforming growth factors (TGF-alpha, TGF-beta1 and TGF-beta2).

RESULTS: Ascorbic acid was found to reduce the proliferation of cells and induce apoptosis by the modulation of p53, p21, Bcl-2 and Bax.

CONCLUSION: The results of this study show the anti-proliferative effects of AA against leukemic cells.

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