Abstract Title:

Serum vitamin C and spinal pain: a nationwide study.

Abstract Source:

Pain. 2016 Jul 18. Epub 2016 Jul 18. PMID: 27434504

Abstract Author(s):

Clermont E Dionne, Danielle Laurin, Thérèse Desrosiers, Belkacem Abdous, Natalie Le Sage, Jérôme Frenette, Myrto Mondor, Sylvie Pelletier

Article Affiliation:

Clermont E Dionne


Back pain brings about one of the heaviest burden of disease. Despite much research, this condition remains poorly understood and effective treatments are frustratingly elusive. Thus, researchers in the field need to consider new hypotheses. Vitamin C (ascorbic acid) is an essential co-factor for collagen crosslinks, a key determinant of ligament, tendon and bone quality. Recent studies have reported high frequency of hypovitaminosis C in the general population. We hypothesized that lack of vitamin C contributes to poor collagen properties and back pain. We conducted this study to examine the associations between serum concentration of vitamin C and the prevalence of spinal pain and related functional limitations in the adult general population.This study used nationwide cross-sectional data from the U.S. National Health and Nutrition Examination Survey (NHANES) 2003-2004. Data were available for 4,742 individuals aged≥20 years.Suboptimal serum vitamin C concentrations were associated with the prevalence of neck pain (adjusted odds ratio (aOR): 1.5; 95% confidence interval (CI): 1.2-2.0), low back pain (aOR: 1.3; 95% CI: 1.0-1.6), and low back pain with pain below knee (aOR: 1.3; 95% CI: 1.0-1.9) in the past three months, self-reported diagnosis of arthritis/rheumatism (aOR: 1.4; 95% CI: 1.2-1.7), and related functional limitations' score (adjusted difference of means (aB): 0.03; 95% CI: 0.00-0.05).The prevalence of hypovitaminosis C in the general population is high. Our study shows associations betweenvitamin C and spinal pain that warrant further investigation to determine the possible importance of vitamin C in the treatment of back pain patients.

Study Type : Human Study

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Sayer Ji
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