The effect of magnesium supplementation on anthropometric indices: A systematic review and dose-response meta-analysis of clinical trials.
Br J Nutr. 2020 Jul 28:1-35. Epub 2020 Jul 28. PMID: 32718360
The aim of this study is to determine the determine effects of magnesium supplementation on anthropometric indices Consist of body weight (BW), waist circumference (WC), body mass index (BMI) and body fat percentage (BF%). In this systematic review and dose-response meta-analysis, we searched PubMed, Cochrane Library, Scopus, Web of Science and Google Scholar from databases inception up February 2020 for relevant randomized controlled trials. Quality of evidence was evaluated using the Cochrane Collaboration Tool. All of outcome in this meta-analysis were pooled using Random Effect Model. Analysis of dose-response for magnesium dosage was carried out using a fractional polynomial model. The systematic review and metal analysis include Twenty-eight RCTs, comprising 2013 participants. There were no significant changes in anthropometric indices after magnesium supplementation in the overall analysis. However, subgroup analysis revealed that magnesium supplementation decreases WC in subjects with BMI>30 (obese) [12 trials, n = 997 participants; weighted mean difference (WMD) = -2.09 cm, 95% CI: -4.12 to -0.07, p =0.040; I2 = 0%]. Dose-response analysis revealed a non-significant nonlinear effect of supplementation dosage on anthropometric indices. The results suggest that magnesium supplementation is associated with lower WC only in obese subjects. However, more high-quality studies are needed to clarify the nature of this association.